partners > UGR

University of Granada, Centre for Biomedical Research

Expertise of the organisation

One of the main activities of CIBM focuses on the exposure assessment of human populations to environmental chemicals, in particular endocrine disrupters, including the design and performance of epidemiological studies (cohorts, case-control, and cross-studies) using the Regional Health Public System resources and CIBM laboratory facilities.

Role in the project

This partner is responsible for the delivery and preparation of of human tissue specimens from case-control studies. In collaboration with other partners they are developing an optimal sample preparation protocol suitable for the analyses carried out in CONTAMED. They are also responsible for the compilation of new data on the concentration of endocrine disrupting chemicals (EDCs) found in human tissues and will be involved in the production of a final report on human cumulative exposure assessments for EDCs for use by regulatory agencies in the EU. They participate in the selection of candidate chemicals that will be subjected to concentration-response analyses in in vitro assays. This partneruses the A-Screen to carry out in vitro mixture studies, metabolomic biomarker identification, epidemiological analysis of case control studies for cumulative EDC exposure and grouping of EDCs in human tissues. This will contribute to the assessment of the significance and usefulness of cumulative EDC exposure biomarkers for further work with European cohorts and for human biomonitoring strategies in Europe.

Key persons involved

		Group leader, Professor Nicolas Olea, is full Professor at the School of Medicine of the University of Granada and Head of the Research Unit of the University Hospital. He leads the Spanish Conference on EDC. He specialized in medicine at the Hospital Clinico in Granada in Nuclear Medicine-Hormones Lab (1980), and he was a postdoc at the Institut Jules Bordet in Brussels (1982-1985) and Tufts University in Boston (1987-1990).